Yes. An approved ESTA can be used for multiple trips to the United States while it remains valid.
It is generally valid for two years from the date of approval or until your passport expires, whichever comes first.
You do not need to submit a new application for every trip. However, each stay under the Visa Waiver Program is limited to a maximum of 90 days.
Before traveling, check that your passport and ESTA approval are still valid.